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We have 4 hotels in Murphysboro.

 
 
Americas Best Value Inn Murphysboro Carbondale Star Rating 2        
128 E. Walnut Street

A 3.8-mile drive to Lake Murphysboro State Park, this casual budget lodging is also 7 miles to Southen Illinois University.Rooms are accessed through exterior corridors and include free WiFi and TVs with premium cable channels, plus minifridges, coffeemakers and microwaves.
Kite Hill Vineyards Star Rating 3        
83 Kite Hill Road

Set on a Shawnee Wine Trail vineyard, this rustic B&B is a quarter-mile off Highway 127 and 14 miles from Giant City State Park.The 2 quaint rooms come with free WiFi, cable TV and private baths.A 3-course gourmet breakfast is served in an elegant formal dining room.
Green Retreat Star Rating 2.5        
6096 Chautauqua Road

GreenRetreat is minutes from SIU, Carbondale, Murphysboro, and on the Shawnee Hills Wine Trail. We combine green technologies, world class accommodations and professional meeting spaces with our working farm activities and horse stables. We are happy to host individuals and groups of up to 35.
Apple Tree Inn Murphysboro Star Rating 2        
200 North Second Street

Apple Tree Inn Murphysboro provides a comfortable setting while in Murphysboro.The hotel has 29 rooms offering all the essentials to ensure an enjoyable stay.Apple Tree Inn Murphysboro is under a 15-minute drive from Southern Illinois Airport.
 
 
More on Murphysboro .
 
Murphysboro is a city in and the county seat of Jackson County, Illinois, United States. The population was 7,970 at the 2010 census. The city is part of the Metro Lakeland area. The Mayor of Murphysboro is Will Stephens.